12:30 CET 
06:30 am ET 

OFFICIAL START OF THE MEETING
(zoom open from 6:15 ET / 12:15 CET)

12:30-12:45

06:30-06:45

(15)

Welcome and Introduction
Greetings from the organizers: Uta Dirksen, Germany & Markus Wartenberg, SPAEN / Deutsche Sarkom-Stiftung

12:45-13:20

06:45-07:20

(35)

Chair: Dr. Yasmine Uhlenbruch / Markus Wartenberg

A journey through time: 100 years of Ewing Sarcoma- Cancer Man Ewing-ASCO-MSKCC-lessons learned from early trials

Heribert Jürgens, Germany / Alan Craft, UK / Paul A. Meyers, USA

13:20-14:40

07:20-08:40

(80)

Chair: Kamil Dolecki / Anna Raciborska

The Status Quo of treatment and care of Ewing’s Sarcoma:
Lessons learned

The clinicians‘ perspective 60'

• Bernadette Brennan, UK: Lessons learned from Euro-Ewing 2021 (15`)
• Katherine Janeway, USA: Lessons learned from AW 1031 (15`)
• Uta Dirksen, Germany: Lesson learned from Ewing 2008 (15`)
• Steve DuBois, USA: Lessons learned from AW 1221 (15`)

The patients‘ perspective 20’

Yasmine Uhlenbruch, Germany / Zoe Davison, Bone Cancer Research Trust UK

14:40-15:10         BREAK
08:40-09:10

15:10-16:40

09:10-10:40

(90)

Chair: Patrik Grohar, Sandra Strauss

Basic Research: News and Updates/Young Scientists

• Oliver Delattre, France: EWSR1-Fli1-best of the 90^th-till today (15‘)
• Thomas Grünewald, Germany: DISCOvery- best of biomarker and targets (15‘)
• Markus Metzler, Germany& Eleni M Tomazou, Austria: Blood is a quite peculiar juice (15‘)
• Poul Sorensen, Canada: Metastatic efficiency in EWS or how to create a warm nest (15‘)
• Katia Scotlandi, Italy: Small is powerful - exos and miRNAs (15‘)
• Sue Burchill, UK: Finding and targeting the cells responsible for progression and relapse (15‘)

16:40-17:00         BREAK
10:40-11:00

17:00-18:30

11:00-12:30 

Chair: Wolfgang Hartmann, Patrick Schöffski

Basic Research: News and Updates/ Young Scientists

• Stefan Zöllner, Germany: Consider PADI (15‘)
• Didier Surdez, Switzerland: Mus musculus – a powerful tool in translation (15‘)
• Wiebke Guder/Maximilan Kerkhoff, Germany: CAM can model (15‘)
• Heinrich Kovar, Austria: Networks of EWS-FLI1 (15‘)
• Enrique de Álava Casado, Spain: What do pathologists think about – CARs? (15‘)

18:30-20:00

12:30-14:00

(90)

Chair: Sebastian Bauer, Bass Hassan

Relapse in Ewing Sarcoma:

New ideas and innovations from bench to bedside

• Martin McCabe, UK: rEECur (15’)
• Patrik Grohar: TrabectIrino (15’)
• Stefan Burdach/Uwe Thiel, Germany: Engineered TCR T-cells (SB) and clinical implication (UT) (15’)
• Claudia Rössig, Germany: How to get GD2 CAR-T cells on the road. (15’)
• Jeffrey A. Toretsky, USA / Stefan Zoellner, Germany / Joseph A Ludwig, USA:
  From YK 4-279 (JAT) to YK-4-279 & VCR (SZ) to T216 Phase I/II (JAL) (15’)
• Emely Theisen, Damon Reed, USA: Why do NURDs and LSD-1 serve as a target in Ewing Sarcoma (ET) – News from Seclidemstat phase I (DR) (15’)

20:00 CET 
14:00 ET

END of DAY 1

09:00 CET
03:00 am ET 

START OF DAY 2
(Zoom open from 8:45 CET)

09:00-09:30

03:00-03:30

 (30)

Organized by SPAEN

A powerful partnership: Experts and Patient Advocates working together against sarcomas

Ornella Gonzato, SPAEN
Helene Loewen / Mieke Bading

09:30-09:40
03:30-03:40       BREAK

09:40-11:30

03:40-05:30

(110)

Chair: Anna Raciborsca, Rob Grimer, UK

Local therapy options: What’s new?

• Dimosthenis Andreou, Germany: Surgery - new aspects? (20’)
• Beate Timmermann, Germany: Radiation Therapy: European Strategies (20’)
• Arnold Paulino, USA: Radiation Therapy: American Strategies (20’)
• Philip Heesen, Switzerland: Value of local treatment modalities-results from EWING2008 (20’)

Surgery vs. Radiation Therapy: Case discussions

• Daniela Greto, Italy: Pelvic/Spine Sarcoma (15’)
• Andreas Leithner, Austria: Thoracic Sarcoma (15’)

11:30-11:50       20 min. BREAK

05:30-05:50

11:50-13:10

05:50-07:10

(80)

Chair: Emanuela Palmerini

From Junior to Senior: Ewing Sarcoma in all ages and AYA-cancer

The Youngest: Ewing in Toddlers- case discussions

Juniors: Adolescents & Young Adults

• Stefan Fröhling/Stefan Pfister/HannoGlimm/Uta Dirksen, Germany: HEROES-AYA
• Dan Stark, UK: SIOPE-TYA
• Valerie Laurence, France
• Andrea Ferrari, Italy: Activities with young people – the science behind fun

Seniors: Elderly Ewing sarcoma patients
Prof. Silvia Hofer/ Beate Bode Switzerland: The EWS elderly project (20’)

13:10-13:55 

07:10-07:55

(45)

Chair: Heribert Jürgens, Ruth Ladenstein

Late effects and Quality of life

• Miriam Götte, Germany: Let´s move
• Gabriele Calaminus, Germany: QoL – more than questionnaires
• Lars Hjorth, Sweden / PanCare

13:55

07:55

END OF MEETING & CLOSING REMARKS

LUNCH